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Description
The efficacy of the tri-agonists derives from the anorectic and insulinotropic activities of GLP-1 and GIP and the energy expenditure induction of glucagon (67)
RothCLPerezFAWhitlockKBElfersCYanovskiJAShoemakerAHet alA phase 3 randomized clinical trial using a once-weekly glucagon-like peptide-1 receptor agonist in adolescents and young adults with hypothalamic obesity
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Moreover, this effect can be reversed by specific GLP-1R (exendin-9) antagonists, which means that GLP-1RA may inhibit the proliferation and differentiation of human adipocyte precursors [97,98]
