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Understanding the distinction between the entities involved in the MEDVi program is important when analyzing how the platform operates

Leptin promotes the proliferation and neuronal differentiation of neural stem cells through the cooperative action of MAPK/ERK1/2, JAK2/STAT3 and PI3K/AKT signaling pathways

In turn, this increased SCFA production, particularly butyrate

In studies using the Duchenne muscular dystrophy mouse model ( mdx ), both the genetic crossing of mdx mice with Mstn / mice and the administration of the MSTN-neutralizing antibody mRK35 led to similar outcomes, specifically increased muscle mass and improved grip strength.[24,25] However, another mouse study reported that Mstn / mice, despite having increased muscle mass, did not exhibit a corresponding increase in muscle strength.[26] Although there are conflicting results regarding the ability of MSTN inhibition to improve muscle functions, such as muscle strength, most studies consistently show that inhibition of MSTN results in a significant increase in muscle mass