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Most patients treated for cardiovascular disease have a BMI of at least 27, suggesting that many patients could benefit from semaglutide regardless of their starting weight

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By hitting four different hormone receptors at the same time, we hope to improve the chances of averaging out such variation toward the goal of achieving greater and more consistent overall effectiveness. A second issue is that patients tend to regain weight after discontinuing currently available GLP-1 related drugs, said Beinborn, who notes that lifestyle changes should ideally be a complement to medication treatment

In a pooled analysis of clinical trials assessing patients with heart failure with preserved ejection fraction (HFpEF), including the STEP HFpEF and STEP HFpEF DM trials, as well as in the FLOW and SELECT trials, semaglutide improved New York Heart Association (NYHA) class IIIV symptoms, physical limitations, exercise function, associated with a 30% reduction of N-terminal pro-brain natriuretic peptide and a 31% reduction in the composite endpoint of cardiovascular death and the need for treatment intensification or hospitalization for heart failure-related events (HR 0.69