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Combination therapy is typically considered when monotherapy or dual therapy with other agents (such as metformin) fails to achieve adequate glycaemic targets, or when patients require additional cardiovascular or renal protection

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Healthcare providers typically recommend these treatments for patients with significant medical needs and patients with a BMI above 30

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SELECT also showed better cardiovascular outcomes in persons with obesity and without diabetes who had previously undergone coronary artery bypass graft surgery [126]

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