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J., & Obesity (2021)
A 2025 meta-analysis published in Frontiers in Pharmacology confirmed this hierarchy, ranking tirzepatide as producing the most significant weight reduction among all available incretin-based therapies, followed by semaglutide, then liraglutide
The figure below is a visual depiction of the importance of L cells
GLP-1RAs make a direct protective impact on the endothelium by the GLP-1R-dependent AMPK/Akt/eNOS pathway [105]
