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OFarrell M, Almohaileb FI, le Roux CW

During this stage, 300 articles were excluded due to irrelevance to the research question or failure to meet the inclusion criteria (22 clinical trials, 43 reviews or other unfitting literature, 112 wrong cell type, 49 wrong focus, 10 wrong drugs, 57 in vivo, 2 retractions, 3 no abstract and 2 not peer reviewed yet)

Research from 2021 has found that, in conjunction with appropriate lifestyle habits, they can help people lose a significant amount of weight or maintain weight loss

148 Hence, IR promotes the pathology of AD by reducing amyloid clearance and increasing tau hyperphosphorylation neurofibrillary tangles, 149 both of which are associated with cognitive impairment