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[168] While short-term use for specific situations like jet lag is well-established, the safety and efficacy of long-term melatonin supplementation remain areas of ongoing research

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Risk of Hypoglycemia: While GLP-1 medications are not typically associated with an increased risk of hypoglycemia when used as monotherapy, they may potentiate the effects of other antidiabetic medications that can cause hypoglycemia, such as sulfonylureas or insulin