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Heres how each one typically plays out

Several factors increase your likelihood significantly: History of GERD or acid reflux , even if it was well-controlled before starting tirzepatide Hiatal hernia , which already weakens the lower esophageal sphincter Obesity , which increases abdominal pressure (though this improves as you lose weight on the medication) Smoking , which relaxes the esophageal sphincter Certain medications like NSAIDs, calcium channel blockers, or bisphosphonates that independently increase reflux risk Eating large meals or eating close to bedtime If you had occasional heartburn before starting tirzepatide, the medication can amplify it significantly during the early weeks

Funding NIHs National Institute on Drug Abuse (NIDA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Aging (NIA), and National Cancer Institute (NCI).

Lockard said