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The Limitations You Should Know: Dependency, Cost, and Side Effects Despite benefits, GLP-1 medications present challenges such as dependency, rebound weight gain upon stopping treatments, high costs especially in emerging markets, and side effects like nausea or digestive discomfort

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Ethics declarations Ethical Approval The experimental animal protocol of this work was approved by the Mansoura UniversityInstitutional Animal Care and Use Committee (IACUC, Code number: MU-ACUC(SC.MS.23.07.27)), ensuring compliance with the guidelines outlined in the National Institutes ofHealth Guide for the Care and Use of Laboratory Animals, conforming to ARRIVE guidelines andconducted under U.K

4 Triangulate Everything Validate findings across multiple independent sources