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In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin

Estimates were adjusted for baseline covariates (see online Supplementary Methods) to address any residual confounding

Some insurance plans cover the medication for patients who meet specific criteria, such as having a BMI over 30 or weight-related health conditions

Ranked second is Novo Nordisks diabetes drug Ozempic (Semaglutide), which generated DKK 32.721 billion (~$4.6 billion) in Q1 2025, an 18% YoY increase (exchange rate: 1 DKK = $0.141)