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doi: 10.1016/j.tcm.2015.10.004 19
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Moreover, in the AMPLITUDE-O, HARMONY OUTCOMES and SUSTAIN-6 trials [50,56,59], there were significant reductions in the expanded composite outcome, defined as hospitalisations for unstable angina and urgent coronary revascularisations

8 Future directions The advancement of GLP-1 receptor agonists is progressing towards more refined treatment strategies, with tirzepatide at the forefront of research as a dual GIP/GLP-1 receptor agonist (Nauck and DAlessio 2022)
