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It remains unclear whether improvements in depressive symptoms reflect a direct neuropsychotropic effect of GLP1RAs or are secondary to indirect benefits such as improved glycaemic control, weight loss and reductions in systemic inflammation

Semaglutide is the active ingredient in three brand-name prescription drugs Ozempic , Wegovy , and Rybelsus all of which are glucagon-like peptide 1 receptor agonists , commonly called GLP-1s