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Hence, GLP-1RAs can be utilized as an adjunct alongside metformin as a first-line treatment for type 2 DM or, in specific cases, as a preferred therapeutic agent when additional benefits for cardiovascular or renal protection are required [84]

GLP-1RA-mediated benefits on blood pressure accounted for 15% weight loss could induce reversal of early-stage chronic kidney disease and microalbuminuria at 24 months follow-up [73]

Weight loss: The target weight loss at this point is a pound a week minimum until one gets to within five pounds of an agreed upon target weight

KEGG pathway analysis has revealed that the MAPK, PI3K and Wnt pathways are involved in this process (197, 198)