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Research has suggested GLP-1s may reduce the risk of heart attack and stroke in people with diabetes or obesity

Animal studies have demonstrated Berberines anti-obesity mechanisms, including the inhibition of adipocyte differentiation through downregulation of adipogenic genes such as Liver X Receptors (LXRs), Peroxisome Proliferator-Activated Receptors (PPARs), and Sterol Regulatory Element-Binding Proteins (SREBPs)

GLP-1 medications commonly cause gastrointestinal side effects, which may overlap with or worsen Crohn's symptoms

Blood pressure-lowering efficacy of antihypertensive drugs and their combinations: a systematic review and meta-analysis of randomised, double-blind, placebo-controlled trials