glp-1 agonist mechanism of action of [25] GLP1-GIP receptor co-agonists: a promising
Description
These conditions may rule out tirzepatide entirely, making alternatives not just preferable but medically necessary
![glp-1 agonist mechanism of action of [25] GLP1-GIP receptor co-agonists: a promising](https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00592-024-02300-6/MediaObjects/592_2024_2300_Fig1_HTML.png)
In other studies, exendin-4 was found to decrease IL-6 levels, as well as NF-kB and cyclooxygenase1 (COX1), all of which are important mediators of inflammation [42,80]
![glp-1 agonist mechanism of action of [25] GLP1-GIP receptor co-agonists: a promising](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs13300-019-0669-4/MediaObjects/13300_2019_669_Fig3_HTML.png)
If you take semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) and are dealing with frequent loose stools, you are not alone
![glp-1 agonist mechanism of action of [25] GLP1-GIP receptor co-agonists: a promising](https://www.ijbs.com/v17/p2050/toc.jpg)
For more frequent symptoms, histamine-2 receptor antagonists (H2RAs) such as famotidine may be used, though patients should be counseled that these medications may take 30-60 minutes to provide relief
![glp-1 agonist mechanism of action of [25] GLP1-GIP receptor co-agonists: a promising](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a3/8189979/5850374cc9c4/12325_2021_1710_Fig1_HTML.jpg)