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Indeed, besides a familial component in insulin resistance, as in general population, patients with PWS have fairly low fasting insulin concentrations and a lower incidence of insulin resistance compared to that expected considering the body mass index (BMI), probably due to a greater distribution of adipose tissue in the subcutaneous than in visceral site [15, 29, 30]

IDF, 2021

Undertaking a detailed literature review of gastrointestinal hormones he concluded there was no convincing evidence to demonstrate that duodenal mucosal extracts had any impact on blood glucose (Creutzfeldt

Nausea and vomiting were the most frequently reported side effects, followed by diarrhea (8.6%), fatigue (6.3%), and constipation (5.7%)