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Theoretical or documented interactions include: Immunosuppressants (particularly ciclosporin, where clinical interaction has been documented) Medications metabolised by CYP3A4 or CYP2D6 enzymes Medications that are P-glycoprotein substrates Consult your pharmacist or GP before taking berberine alongside any regular medications, particularly those with a narrow therapeutic window

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and (d) (i) either reported taking their current dose for 30 days of Semaglutide/Tirzepatide or (ii) did not report taking these medications (as a control group) for diabetes or weight loss

The average AP firing frequency was increased by Ex-4 (from 3.70.8 to 4.20.8 Hz, n =21), but this increase was not statistically significant ( P =0.282, paired t test) (Supplemental Fig