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UK guidance typically recommends a more gradual weight loss of 0.5-1 kg per week where feasible

Overview of Semaglutide Antioxidant Benefits, 2024 A preclinical study showing that semaglutide significantly reduced systemic and central nervous system inflammation in a rodent model, suggesting potential anti-inflammatory and neuroprotective effects of GLP-1 therapies

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Despite the huge difference in their numbers, with only a few thousand lymphocytes invading the brain and more than 50 times higher numbers of resident microglia, microglia could amplify the impact of T cells on the cerebral immune environment, making T cells the largest subtype of white blood cells contributing to secondary inflammatory damage after ischemia (70)