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5.8 Heart Failure Cases of worsening congestive heart failure (CHF) and new onset CHF have been reported with TNF blockers

5.3 Lean Mass and Body Composition Weight loss trials indicate that: 2040% of weight lost may include lean mass, depending on protein intake and physical activity. Lean mass loss itself does not cause micronutrient deficiency, but it may reflect: Reduced protein intake Reduced intake of iron- and zinc-rich foods Reduced intake of B vitamins Clinical oversight of protein intake is therefore a practical nutritional priority

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Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014