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We were all stunned when the data came back pretty clearly saying that, for certain kids, these medications can really have a beneficial health effect, Bolling, who is not involved in Demis care, tells TODAY.com

Chronic alcohol use, malnutrition, prolonged vomiting, hyperemesis gravidarum, cancer cachexia, dialysis, bariatric surgery, or prolonged IV glucose without thiamine

Groups losing weight rapidly took longer to plateau, typically between 36 and 48 weeks into treatment, compared to about 24 weeks for those losing weight more gradually

Zepbounds range of available doses (from 2.5 mg to 15 mg) gives significant room for adjustment