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Cell 24 , 23982405 (2013)

A systematic review published in eClinicalMedicine analyzed 18 randomized controlled trials involving 3,771 participants and found that discontinuing GLP-1 receptor agonists resulted in an average weight regain of 5.63 kg, along with an HbA1c increase of 0.25%

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The drug has a long half-life, which means it can be administered monthly or less frequently, giving the drug the potential to improve adherence and long-term weight control, according to Jay Bradner, executive vice president of research and development at Amgen