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GLP-1s can lead to significant weight lossup to 22.5% of body weight

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Instead, GIP may counteract nausea and vomiting via direct modulation of the area postrema/NST emesis circuitry (169) and exert protective effects on unfavorable altered gut motility ( 5.4 GIP and GLP-1 effects on lipid and glucose metabolism in adipose tissue and liver Fat and liver are two organs that play key roles in lipid and glucose metabolism, working together in concert and complimentarily to maintain lipid and glucose homeostasis

This additional mechanism may translate to better blood sugar control and more sustainable weight loss, especially for people whose bodies respond less robustly to single-receptor GLP-1 therapy alone