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Notably, given that SGLT-2 is expressed in the brain, which is consistent located with enhanced cFos expression induced by SGLT-2is, we hypothesize that SGLT-2is may cross the BBB via receptor-mediated transcytosis

Dietary changes : Patients starting GLP-1 therapy often make significant dietary modifications, including increased vegetable and fruit consumption (which have high water content) and reduced processed food intake

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Long-term monitoring of patients taking semaglutide for type 2 diabeteswhere the compound has been prescribed since 2017reinforces that sustained use does not reveal hidden risks that emerge only after years of exposure