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As estrogen declines during perimenopause and menopause, insulin sensitivity can decrease

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Other Serious Concerns MedlinePlus reports several serious side effects that need medical attention: Pancreatitis symptoms: Severe stomach pain radiating to your back Kidney problems: Changes in urination, swelling Allergic reactions: Rash, itching, difficulty breathing Thyroid issues: Lump in your neck, hoarseness Who Should Not Take Semaglutide

The next generation of regimens may involve combining GLP-1 or dual GIP/GLP-1 receptor agonists with other nutrient-based hormone receptor agonists or antagonists that offer equal or greater effectiveness with fewer gastrointestinal adverse effects