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The circumventricular organs, including the area postrema, lack a complete blood-brain barrier, allowing circulating GLP-1 and GLP-1 receptor agonists more direct access to these critical regulatory centers
Combining GLP-1 receptor agonists (GLP-1 RAs) with Metformin has shown promising results for women with PCOS, especially in tackling weight management and improving both metabolic and reproductive health
Future research is warranted to characterize the effects of GLP-1 RA therapy and post-cessation on SO risk in older adults, as well as to establish MNT protocols and define evidence-based clinical approaches tailored to this population
