half life of glp 1 agonists A) Half-life extension mechanisms acylated GLP-1 analogs. (B) Mean GLP-1 receptor agonists | How

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Consistent with a role of vagal afferents and vagal afferent GLP-1 receptors in the eating-inhibitory effect of peripheral endogenous GLP-1, virus-mediated knockdown of GLP-1R in vagal afferent neurons increased meal size, accelerated gastric emptying, and reduced prandial insulin secretion in rats, while not affecting 24 h food intake or body weight [518]

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doi: 10.1016/j.molmet.2018.12.001