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July 17, 2025

Yet, patients and clinicians should consider this evidence when discussing potential risks and patients' values and preferences that might affect the risk/benefit balance

When looking at specific mental health conditions, semaglutide use was linked to significantly lower risks of worsening depression, anxiety, and substance use disorders

Similarly, the evaluation of gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which occur frequently with GLP-1RAs (42) and have a major influence on the adherence to such treatment over time, have often been assessed in clinical trials solely via participant self-report, which is known to be unrelaible (eg, symptoms may not be volunteered due to embarrassment or poor recall) (43, 44)