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The one clinical trial that has been completed found that exenatide had no impact on cocaine use or subjective euphoria after using cocaine (Angarita G et al, Drug Alcohol Depend 2021;221:108614)
Semaglutide and tirzepatide work by mimicking naturally occurring hormones involved in appetite and fullness

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To probe changes in gut gene expression potentially linked to the lipid phenotypes observed in these mice, we measured mRNA levels in the jejunum corresponding to a subset of genes involved in lipid metabolism
