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A reasonable starting framework, based on extrapolation from GLP-1 nasal delivery literature, might look like this: Conservative approach: Begin with 0.5-1mg per nasal actuation, administered once daily

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Fras JP, Davies MJ, Rosenstock J, Prez Manghi FC, Fernndez Land L, Bergman BK, Liu B, Cui X, Brown K, for the SURPASS-2 Investigators

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