Semaglutide: A Weight Loss Breakthrough
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Description
These findings support semaglutide as a disease-modifying therapy rather than a symptom reliever
Mosenzon O, Blicher TM, Rosenlund S et al (2019) Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial
doi: 10.1002/oby.22653
Regarding pharmacodynamics, TZP appears as a biased GLP-1R-GIPR co-agonist, because of its positive effects on cAMP generation over -arrestin recruitment, which is conversely stimulated by GLP-1R
