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Initiation of opioid prescription and risk of suicidal behavior among youth and young adults
Semaglutide targets the GLP-1 receptor only, while Tirzepatide targets both GLP-1 and GIP receptors making it a dual-action medication
[DOI] [PubMed] [Google Scholar] 59.Rusnak DW, Lai Z, Lansing TJ, Rhodes N, Gilmer TM, Copeland RA
Interestingly, exogenously administered GIP and GLP-1 seem to access the brain predominately via leaks in the bloodbrain barrier, where the underlying neuronal tissue has dense expression of their receptors [11,12,13, 17] (Fig
