semaglutide cardiac effects ameliorates pressure overload-induced hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome Effects of semaglutide on mortality,
Description
For studies with a calorie-restricted and body-weight-loss-matched control group, HFHS diet (58 kcal% fat, D12331i, Research Diets) was weighed and provided as one separate pellet per mouse at the time of injection

Clinical studies in the US show patients could lose up to 22% of their body weight after 64 weeks
It is a GLP-1 and GIP agonist, which means it encourages the body to secrete more of certain hormones that help regulate appetite and energy use

Cureus, 16(7), e64738
