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The first study to describe a potential mechanism for this effect on postprandial lipids was published in 2010 (229)

Leucine also mitigates activity- or exercise-related muscle soreness to support the pursuit of physical activity
In patients with clinical evidence or subclinical evidence of CV disease who received standard of care for T2DM, treatment with SEM 0.5 mg was associated with statistically significantly greater reduction in total cholesterol (treatment ratio 0.97, 95% CI 0.95 to 1.00) and greater reduction in LDL cholesterol (treatment ratio), compared with placebo
Fuselier T, Mota de Sa P, Qadir MMF, Xu B, Allard C, Meyers MM, et al
