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Description
Known side effects include nausea, vomiting, and abdominal discomfort
Phase 3 trials with larger populations and longer follow-up periods will be essential to characterise the safety profile more comprehensively
GLP-1 receptor agonists are synthetic analogs or modified versions of this endogenous hormone, designed to resist degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), thereby extending their duration of action from minutes to hours or days
In rats, more severe effects were seen after maternal exposure to semaglutide in the form of visceral abnormalities and major skeletal malformations ( Table 1 )
