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Subjects from the SUSTAIN 6 study treated with sc semaglutide had a 26% reduced risk of a cardiovascular events compared with the risk among individuals who received a placebo [57]

But the delivery system requires significantly more patient education and diligence

In some cases, patients were getting up to 20 times more of the drug than they should have, either because they were injecting themselves with larger doses than intended or because their prescribers were "miscalculating" the dose

For example, rats administered exendin-4 into the HPCv only decrease their consumption of a high fat/sugar diet 6h after the infusion, but at the 24h timepoint chow intake is also reduced [69]