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This approach minimizes medication exposure while still delivering results, and your dose may need to go up later only if weight loss plateaus or your goals require acceleration

Talk to your doctor to see if there are any underlying causes of weight gain, such as hormonal imbalances, medications or metabolic conditions

Efficacy and safety of oral small molecule glucagon-like peptide 1 receptor agonist danuglipron for glycemic control among patients with type 2 diabetes: a randomized clinical trial

In higher doses of 50 mg (which may be prescribed off-label), the average weight loss is 15.1% in 68 weeks, according to a separate study