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The study population included a broad range of subjects with varying severities of RI: mild, moderate, severe, and a group with ESRD undergoing regular hemodialysis

Some of the most common side effects (but not extremely frequent) are: diarrhea oily stools or spotting stomach discomfort gas more frequent bowel movements that may be hard to control Additional side effects include: loss of appetite diarrhea or constipation increased energy increased thirst dizziness skin rash sexual problems in males chills runny nose irritability or feeling down These symptoms may subside after the body adjusts to the medication