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Why Effects Extend Beyond Blood Sugar The broad benefits of GLP-1 medications stem from addressing underlying metabolic dysfunction rather than just treating elevated glucose: Weight loss addresses root causes: Excess weight drives insulin resistance, the core problem in Type 2 diabetes

GLP-1 also has additional non-incretin functions, including glucagon secretion repression, gastric motility inhibition, and satiety enhancement

Once-daily oral semaglutide (Rybelsus) achieves an HbA 1c reduction of around 1115 mmol/mol in people with type 2 diabetes less than injectable semaglutide but comparable to other long-acting injectable GLP-1 RAs