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23,7880 In one recent study nested in the Shanghai Cohort Study which enrolled over 18,000 men from 19861989 and followed them for lung cancer development, we found a significant relationship between urinary total cotinine (cotinine plus its N-glucuronide) and lung cancer development based on analysis of total cotinine in over 900 urine samples, all from smokers, even after taking into account number of years of smoking and numbers of cigarettes per day
