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Interestingly, in colon cancer, mutp53 selectively releases miR-1246-rich exosomes that are taken up by surrounding macrophages, leading to miR-1246-dependent reprogramming into a tumor-promoting M2 state [92]

This reflects Thailands strong commitment towards protecting people in the country, particularly youth, from the harms of tobacco use as well as fulfilling Thailands obligations under the WHO Framework Convention on Tobacco Control

As previously referred, inflammatory pathways can also be activated by UVR-induced ROS or indirectly by DNA or mitochondrial damage, where both keratinocytes and fibroblasts contribute to the inflammatory condition and extracellular matrix degradation