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"Especially in North Carolina (because) were one of only 12 or 13 states that doesnt have a retail licensing program, and so there are no consequences to retailers who choose to sell tobacco to children under the age of 21." According to the CDC, as of Dec

While the increase was slight from the year before, underage tobacco and vape sales have increased 140 percent since 2019, the increase largely due to the legal age for buying tobacco increasing from 18 to 21

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Despite the availability of techniques capable of quantifying the activity of CYP isozymes such as 1A2, 2B6, 2C9 and 3A4 [8], they are not commonly used in clinical practice