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This is the first time that the remarkable hold that cigarettes can establish after a single experience has been documented from such a large set of data, co-author Peter Hajek said in a statement

The causes of tobacco addiction encompass biological, social, and environmental factors, according to a study by Smoke-Free titled Reasons People Smoke. At the core of tobacco addiction is nicotine , a powerful psychoactive substance that leads to changes in brain chemistry, fostering dependence

But we need more research to know whether this response applies to humans

22 Unfortunately, because of its adverse psychiatric side effects, the drug was not approved for use in the United States