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M1 macrophages exhibit enhanced antimicrobial properties, release pro-inflammatory cytokines such as TNF-, IL-6 and IL-12, and thus promote a Th1 environment [173]

Massachusetts and California enacted the nations first statewide flavored nicotine bans in 2019 and 2020, although both contain exemptions

Claridge R, Gray L, Stubbe M, Macdonald L, Tester R, Dowell AC

While they contain fewer harmful chemicals than traditional cigarettes, they still carry health considerations you'll want to understand before making any decisions