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A medical relations division was created by RJ Reynolds Tobacco Company and advertised in medical journals

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Introduction Frogeye leaf spot disease on flue-cured tobacco is caused by the fungal pathogen, Cercospora nicotianae , first reported in North Carolina, US by Ellis and Everhart (1893)

Coolidge went on to say, [The thought of Hooker and Wise] was carried on with a missionary spirit which did not fail to reach the Scotch-Irish of North Carolina, showing its influence by significantly making that Colony the first to give instructions to its delegates looking to independence