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Only about 5 percent of smokers quit successfully without medications and counseling, and we know that people who have high-risk genetic markers are even less likely to quit on their own, said Li-Shiun Chen, MD, an assistant professor of psychiatry

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We therefore carefully controlled for CST in multivariate analysis and also conducted stratified analysis based on CST so that we could directly contrast smokers versus non-smokers, while essentially holding CST constant

However, studying the health effects of STs will come with its own set of limitations and challenges, since the various ST products can differ greatly in terms of content and bioavailability of its constituents such as nicotine, additives, heavy metals and flavouring agents