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The authorization permits the company to use the following claim for the approved products: "Using ZYN instead of cigarettes puts you at a lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema, and chronic bronchitis." For the travel retail tobacco category, the decision represents another regulatory milestone for smoke-free alternatives, with PMI expanding the number of products in its portfolio that have received FDA modified-risk authorization

Lungs Before and After Smoking Image credit: The lung on the left is damaged from smoking, but after just a few weeks of being tobacco free, the lungs begin to repair themselves

Study participants who had ever used electronic cigarettes even one or two times were referred to as e-cigarette ever-users, while those who reported current use in the past 30 days were classified as e-cigarette current users. Participants who had used electronic cigarettes in the past but not in the past 30 days were defined as e-cigarette ex-users, and those who had never used electronic cigarettes (even one or two times) were categorized as e-cigarette never users. For e-cigarette users, their consumption patterns were assessed by determining the type of e-cigarette they used (disposable, pre-filled cartridge, or refillable tank), their preferred flavor choice (fruit/mint or menthol/bubble gum/cinnamon/chocolate/other), total amount of cartridge use in milliliters for refillable devices per month, the number of days e-cigarettes were used in the past 30 days, and the age at which they began using e-cigarettes

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