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The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1)

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Topography was investigated using puff-level measures (eg, time-to-volume metrics) in addition to a segment-level analysis that separated smoking segments by 5-, 10-, and 30-second intervals

Additionally, hundreds of additives are also incorporated during the manufacturing of cigarettes