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"At a time when many claim to be uncertain about the harms and benefits of e-cigarettes and argue for more studies, these data provide strong longitudinal evidence that e-cigarette use leads to smoking, most likely owing to nicotine addiction," he writes

Nicotine Tob Res 12(2):179183 Chapman F, McDermott S, Rudd K et al (2022) A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic, pharmacodynamic and safety and tolerability profiles of tobacco-free oral nicotine pouches relative to cigarettes