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Smoking is linked to a weakened immune system
The problem becomes even worse if we bear in mind that one pack of cigarettes a day is not enough for most individuals with tobacco addiction
Poisson regression analysis was used to estimate the risk ratios (RRs) with 95% confidence intervals (CIs) for 12 subtypes of congenital anomalies associated with the timing (i.e., before pregnancy, and during three different trimesters of pregnancy) and intensity (i.e., number of cigarettes consumed per day) of maternal cigarette smoking

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