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Smokers who did not have a history of depression when they started smoking are more likely to become depressed than nonsmokers

For instance, EC use was shown to induce significant changes in the oral microbiome, with increased -diversity in saliva and shifts in -diversity in buccal mucosa compared to nonsmokers

And smokers do not appear to be shifting to e-cigarettes, devices which have generally remained unpopular in the community

These symptoms lead many people to self-medicate with drugs, alcohol, or nicotine, thinking that the temporary and immediate effects of these substances somehow help them deal with what they are experiencing inside